Kranji Secondary was established in 1995 and was temporarily sited in Chestnut Drive Secondary School. In 1996, the school was relocated to its present premises at 61 Choa Chu Kang Street 51. The school came under MOE’s Project for Renovating and Improving Existing Schools (PRIME) from 2016 to 2018. On 11 December 2018, the school shifted to its completed new premise after PRIME upgrading.